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About Top Science

TOP Science is a Biochemical technology Co.LTD, And we provide a full range of CRO services that cover the entire drug development pipeline, including contract research for compound synthesis, biochemical and cellular analysis,and marketing research.

Analysis of off-target effects of CRISPR/Cas-derived RN

RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component originated from Streptococcus pyogenes. These enzymes cleave chromosomal DNA, whose sequence is complementary

2013-11-27 11:53:30 | [Read more...]

17β-Estradiol Inhibits Phosphorylation of Stromal Inter

Sex plays a significant role in the development of lung diseases including asthma, cancer, chronic bronchitis, and cystic fibrosis. In cystic fibrosis, 17β-estradiol (E2) may inhibit store-operated Ca2+ entry (SOCE) to impinge upon airway secretions, leaving females at greater risk of contracting lung infections. Stromal interaction molecule 1 (STIM1)-mediat

2013-11-25 9:47:09 | [Read more...]

Therapeutic efficacy of potent neutralizing HIV-1-speci

Dan H. Barouch,James B. Whitney,Brian Moldt,Florian Klein,Thiago Y. Oliveira,Jinyan Liu,Kathryn E. Stephenson,Hui-Wen Chang,Karthik Shekhar,Sanjana Gupta,Joseph P. Nkolola,Michael S. Seaman,Kaitlin M. Smith,Erica N. Borducchi,Crystal Cabral,Jeffrey Y. Smith,Stephen Blackmore,Srisowmya Sanisetty,James R. Perry,Matthew Beck,Mark G. Lewis,William Rinaldi,Arup K

2013-11-22 10:37:08 | [Read more...]

Pest invasion through online shopping

2013-11-18 19:00:03 | [Read more...]

Randy Schekman awarded 2013 Nobel Prize in Physiology o

2013-11-16 15:13:01 | [Read more...]

Sense of touch

Restoring the sense of touch. Image courtesy of Ed Whitman, Johns Hopkins Applied Physics Lab. "Restoring the sense of touch with a prosthetic hand through a brain interface," by Gregg. A. Tabot, et al.

2013-11-15 10:04:50 | [Read more...]

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