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About Top Science

TOP Science is a Biochemical technology Co.LTD, And we provide a full range of CRO services that cover the entire drug development pipeline, including contract research for compound synthesis, biochemical and cellular analysis,and marketing research.


What makes a sex? There are two answers to this question, the master regulators that tell organisms which sex they should be and the downstream genes that encode the molecules that make sexual behavior possible. Answering these questions is easier in the brewer’s yeast, Saccharomyces cerevisiae, where there are two mating types, called a and alpha, and si

2013-12-9 9:16:05 | [Read more...]

17β-Estradiol Inhibits Phosphorylation of Stromal Inter

Sex plays a significant role in the development of lung diseases including asthma, cancer, chronic bronchitis, and cystic fibrosis. In cystic fibrosis, 17β-estradiol (E2) may inhibit store-operated Ca2+ entry (SOCE) to impinge upon airway secretions, leaving females at greater risk of contracting lung infections. Stromal interaction molecule 1 (STIM1)-mediat

2013-11-25 9:47:09 | [Read more...]

Therapeutic efficacy of potent neutralizing HIV-1-speci

Dan H. Barouch,James B. Whitney,Brian Moldt,Florian Klein,Thiago Y. Oliveira,Jinyan Liu,Kathryn E. Stephenson,Hui-Wen Chang,Karthik Shekhar,Sanjana Gupta,Joseph P. Nkolola,Michael S. Seaman,Kaitlin M. Smith,Erica N. Borducchi,Crystal Cabral,Jeffrey Y. Smith,Stephen Blackmore,Srisowmya Sanisetty,James R. Perry,Matthew Beck,Mark G. Lewis,William Rinaldi,Arup K

2013-11-22 10:37:08 | [Read more...]

Randy Schekman awarded 2013 Nobel Prize in Physiology o

2013-11-16 15:13:01 | [Read more...]

Sense of touch

Restoring the sense of touch. Image courtesy of Ed Whitman, Johns Hopkins Applied Physics Lab. "Restoring the sense of touch with a prosthetic hand through a brain interface," by Gregg. A. Tabot, et al.

2013-11-15 10:04:50 | [Read more...]

Structural and biological studies on bacterial nitric o

Nitric oxide (NO) produced by bacterial nitric oxide synthase has recently been shown to protect the Gram-positive pathogens Bacillus anthracis and Staphylococcus aureus from antibiotics and oxidative stress. Using Bacillus subtilis as a model system, we identified two NOS inhibitors that work in conjunction with an antibiotic to kill B. subtilis. Moreover,

2012-9-29 15:34:38 | [Read more...]

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